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[论文/论著] 近期部分论著:
1. Lei Gong, Yuhua Wei, Xin Yu, Jirun Peng, and Xisheng Leng. 3-Bromopyruvic Acid, A Hexokinase II Inhibitor, is an Effective Antitumor Agent on the Hepatoma Cells: in vitro and in vivo Findings. Anti-Cancer Agents in Medicinal Chemistry, 2014 ;14(5):771-776.
2. Zhuqingqing Cui, Xin Yu, Limin Guo, Yuhua Wei, Shengmin Zheng, Wenxia Li, Pengcheng Chen, Jiye Zhu, Jirun Peng. Combined Analysis of Serum Alpha-Fetoprotein and MAGE-A3-Specific Cytotoxic T Lymphocytes in Peripheral Blood for Diagnosis of Hepatocellular Carcinoma. Disease Markers, 2013; 35(6):915–923.
3. 朱卫华,张大方,郑晟旻,金仲田,甘丽云,李澍,冷希圣,彭吉润。微波消融治疗24例结直肠癌肝转移的临床疗效分析。腹部外科,2013;26(2):19-22。
4. PENG-CHENG CHEN, JI-RUN PENG, LEI HUANG, WEN-XIA LI, WEN-ZHEN WANG, ZHU-QING-QING CUI, HUI HAN, LEI GONG, DA-PENG XIANG, SHI-SHI QIAO, XIN YU, YU-HUA WEI, LI-PING MA, NA LI, JI-YE ZHU and XI-SHENG LENG. Overexpression of human telomerase reverse transcriptase promotes the motility and invasiveness of HepG2 cells in vitro. ONCOLOGY REPORTS, 2013, 30: 1157-1164.
5. 丁磊,高宏,陈奕至,黄静,朱煜冰,孔璐,昌红,彭吉润。Claudin-7基因敲除诱导小鼠肠道炎症及其致癌机制的研究。中华普通外科杂志,2013;28(2):120-124。
6. Peng Jirun, Guoxin Zhang, Seon-Ah Ha, Hyun Kee Kim, Jinah Yoo, Sanghee Kim, Jin Zhongtian, Cui Zhuqingqing, Youn Soo Lee,Gi Hwan Gong, Joo Hee Yoon, Hae Nam Lee,Sa Jin Kim, Tae Eung Kim, Eun Young Song, Yun Kyung Lee, Yong Gyu Park, Jin Woo Kim. HCCR-1 for detecting small hepatocellular carcinoma latent in a cirrhotic liver: a prospective cohort study. Gut, 2012; 61(10):1514-1515.
7. Lei Gong, Zhuqingqing Cui, Pengcheng Chen, Hui Han, Jirun Peng, Xisheng Leng. Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II. Med Oncol; 2012; 29(2): 909-914.
8. Lei Gong, Zhuqingqing Cui, Xin Yu, Yuhua Wei, Jirun Peng, Xisheng Leng.Hexokinase II in CD133+ and CD133- hepatoma BEL-7402 Cells. Pathol Oncol Res, 2012; 18(2): 377-381.
9. W Wen, L Zhang, J Peng, J Chen, J Hao, X Li, X Qian, P Zeng, Y Zhang, and Y Yin. Identification of promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the cancer-testis antigen HCA587. Cancer Sci, 2011; 102(8): 1455-1461.
10.解宝江,郑晟旻,彭吉润。消化道恶性肿瘤患者外周血25-羟基维生素D测定的临床意义。河北医药,2011;33(24):3711-3712。
11.Peng Jirun, Guoxin Zhang, Hyun Kee Kim, Seon-Ah Ha, Jin Zhongtian, Qiao Shishi, Cui Zhuqingqing, Gong Lei, Jinah Yoo, Sanghee Kim, Yong Gyu Park, Jing Wang, Yang Yang, Zekuan Xu, Zuhu Huang, Yun Kyung Lee, Eun Young Song, Jin Woo Kim. Clinical utility of alpha fetoprotein and HCCR-1, alone or in combination, in patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Disease Markers, 2011; 30(6): 307–315.
12.Shi-Shi Qiao, Zhu-Qing-Qing Cui, Lei Gong, Hui Han, Peng-Cheng Chen, Li-Min Guo, Xin Yu, Yu-Hua Wei, Seon-Ah Ha, Jin Woo Kim, Zhong-Tian Jin, Shu Li, Ji-Run Peng, Xi-Sheng Leng. Simultaneous Measurements of Serum AFP, GPC-3 and HCCR for Diagnosing Hepatocellular Carcinoma. Hepato-Gastroenterology, 2011; 58:1-6.
13.Hui Han, Ji-Run Peng, Peng-Cheng Chen, Lei Gong, Shi-Shi Qiao, Wen-Zhen Wang, Zhu-Qingqing Cui, Xin Yu, Yu-Hua Wei, Xi-Sheng Leng. A novel system of artificial antigen-presenting cells efficiently stimulates Flu peptide-specific cytotoxic T cells in vitro. Biochem Biophys Res Commun, 2011; 411(3): 530-535.
14.王卉,于鑫,彭吉润,童春荣,武平,李燕燕,康蕊,孙慧鹏。流式细胞术在非造血系统肿瘤骨髓侵犯检测中的价值。中华检验医学杂志,2011;34(2):141-146。
15.Chen L, Ho DW, Lee NP, Sun S, Lam B, Wong KF, Yi X, Lau GK, Ng EW, Poon TC, Lai PB, Cai Z, Peng J, Leng X, Poon RT, Luk JM. Enhanced detection of early hepatocellular carcinoma by serum SELDI-TOF proteomic signature combined with alpha-fetoprotein marker. Ann Surg Oncol, 2010; 17(9): 2518-2525.
16.L Zhao, DC Mou, JR Peng, L Huang, ZA Wu, XS Leng. Diagnostic value of cancer-testis antigen mRNA in peripheral blood from hepatocellular carcinoma patients. World J Gastroenterol, 2010; 16(32): 4072-4078.
17.Lee NP, Chen L, Lin MC, Tsang FH, Yeung C, Peng J, Leng X, Beretta L, Sun S, Day PJ, Luk JM. Proteomic expression signature distinguishes cancerous and nonmalignant tissues in hepatocellular carcinoma. J Proteome Res 2009; 8(3): 1293-1303.
18.金仲田,彭吉润,朱卫华,张大方,甘丽云,李澍,王福顺,朱继业,冷希圣。超声引导经皮微波消融治疗肝转移癌的临床疗效分析。中国普通外科基础与临床杂志,2010;17(3):229-232。
19.Yan-Li Pang, Hua-Gang Zhang, Ji-Run Peng, Xue-Wen Pang, Shu Yu, Qiao Xing, Xin Yu, Lei Gong, Yan-Hui Yin, Yu Zhang, Wei-Feng Chen. The immunosuppressive tumor microenvironment in hepatocellular carcinoma. Cancer Immunology, Immunotherapy, 2009; 58(6): 877-886.
20.彭吉润,朱卫华,张大方,公磊,甘丽云,李澍,金仲田,王福顺,陈雷,朱继业,冷希圣。微波消融结合TACE治疗原发性肝癌疗效分析。中华普通外科杂志,2009;24(11):885-888。
21.金仲田,李澍,彭吉润,李英杰,冷希圣。原发性十二指肠癌的诊断与治疗。中华普通外科杂志,2009;24(2):125-127。
22.Qiao Xing, Xue-Wen Pang, Ji-Run Peng, Yan-Hui Yin, Yan Li, Xin Yu, Shu-Pei Zhou,Yu Zhang, Wei-Feng Chen. Identification of new cytotoxic T-lymphocyte epitopes from cancer testis antigen HCA587. Biochemical and Biophysical Research Communications, 2008, 372 (2) :331–335.
23.彭吉润,冷希圣。NY-ESO-1抗原与肿瘤免疫治疗进展。中国医学科学院学报,2008;30 (4) : 371 – 377。
24.Dong, X.-Y., Peng, J.-R., Ye, Y.-J., Chen, H.-S., Zhang, L.-J., Pang, X.-W., Li, Y., Zhang, Y., Wang, S., Fant, M.E., Yin, Y.-H., Chen, W.-F. PLAC1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients.International Journal of Cancer, 2008, 122( 9);2038 – 2043.
25.Hua-Gang Zhang, Hong-Song Chen, Ji-Run Peng, Xiao-Ying Shang, Jun Zhang, Qiao Xing, Xue-Wen Pang, Li-Ling Qin, Ran Fei, Ming-Hui Mei, Xi-Sheng Leng, Wei-Feng Chen. Specific CD8+ T cell responses to HLA-A2 restricted MAGE-A3 p271–279 peptide in hepatocellular carcinoma patients without vaccination. Cancer Immunology, Immunotherapy, 2007; 56(12): 1945-54..
26.Xin Yi, John M. Luk, Nikki P. Lee, Jirun Peng, Xisheng Leng, Xin-Yuan Guan, George K. Lau, Laura Beretta,Sheung-Tat Fan. Association of Mortalin (HSPA9) with Liver CancerMetastasis and Prediction for Early Tumor Recurrence. Molecular and cellular Proteomics, 2008; 7(2): 315 - 325.
27.王东,彭吉润,朱继业,冷希圣。家兔部分肝脏切除术中应用纤维蛋白胶防治术后出血及胆汁渗漏的实验研究。中国普外基础与临床杂志,2008;15(4):262-265。
28.彭吉润,董南,刘虎威,冷希圣。利用质谱技术对人肝癌细胞系HLE细胞表面自然呈递的MAGE-3 表位进行鉴定。中华外科杂志,2007;45(9):595-597。
29.金仲田,彭吉润,李澍,郁卫东,冷希圣。原发性肝细胞癌消减杂交文库构建及差异表达基因筛选。中华实验外科杂志,2006;23:823-825。
30.周迈,彭吉润,焦岗军,钟朝辉,涂向群,常迎彬,焦岗军,冷希圣。肝癌组织内类阿片肽LVV-血衍吗啡素-6的作用。世界华人消化杂志,2006;14:3020-3025。
31.钟朝辉,焦岗军,杨燊,彭吉润,程西奎,卢军,魏玉华,于鑫,黄迅。蛋白激酶激活受体-2在人类结直肠肿瘤中的表达研究。中华普通外科杂志,2007;22(1):25-27。
32.钟朝辉,李澍,彭吉润,朱继业,冷希圣,周迈,焦岗军,郭晏同,黄迅,魏玉华,于鑫。人肝癌细胞系HCC LM3中生长抑素受体的表达研究。中华普通外科杂志,2006;21: 290-292。
33.王远,彭吉润,黄迅,冷希圣。肝硬化门静脉高压症腹壁浅静脉的腹部CT表现。中国综合临床,2006;22(1):66-68。
34.JR Peng, HS Chen, DC Mou, J Cao, X Cong, LL Qin, L Wei, XS Leng, Y Wang, and WF Chen. Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters. Cancer Lett, Mar 2005; 219(2): 223-32.
35.XA Yang, XY Dong, H Qiao, YD Wang, JR Peng, Y Li, XW Pang, C Tian, and WF Chen. Immunohistochemical analysis of the expression of FATE/BJ-HCC-2 antigen in normal and malignant tissues. Lab Invest, Feb 2005; 85(2): 205-13.
36.彭吉润,董南,刘虎威,冷希圣。HLE细胞抗原多肽的提取、纯化以及初步鉴定。中华普通外科杂志,2005(2 );20(2):117-119。
37.周迈,彭吉润,冷希圣。利用液-质联用技术从一名肝癌患者体内检测出一条天然的阿片类肽——Leu-Val-Val-血衍吗啡素-6。中华肝脏病杂志,2005;13(8):617。
38.Zhou M, Peng JR, Zhang HG, Wang HX, Zhong ZH,Pan XY, Chen WF, Leng XS. Identification of naturally presented MAGE antigen peptides from a patient with hepatocellular carcinoma by Mass Spectrometry. Immunology Letters, Jun 2005; 99(1): 113-21.
39.关心,彭吉润,冷希圣。人树突状细胞与肝癌细胞系HLE 融合细胞的构建。中华肿瘤杂志,2005(8);27(8):465-467。
40.关心,冷希圣,彭吉润,魏玉华,王卉,袁兰。融合快速培养的树突细胞体外诱导特异性抗肝癌免疫反应。中华医学杂志,2005;85(47):3332-3336。
41.X Guan, JR Peng, L Yuan, H Wang, YH Wei, and XS Leng. A novel, rapid strategy to form dendritomas from human dendritic cells and hepatocellular carcinoma cell line HCCLM3 cells using mature dendritic cells derived from human peripheral blood CD14+ monocytes within 48 hours of in vitro culture. World J Gastroenterol, Dec 2004; 10(24): 3564-8.
42.彭吉润,赵力,牟东成,朱继业,黄磊,王东,李澍,冷希圣。以肿瘤-睾丸抗原mRNA为特异性标记评价肝癌患者肝移植的预后。中华普通外科杂志,2004(8 );19(8):464-467。
43.彭吉润,李澍。RT-PCR技术在肝癌患者循环肿瘤细胞检测中的应用。中国实验诊断学,2004;8(3):252-255。
44.王万祥,彭吉润,冷希圣,杜如昱。HCA 587 基因在肝细胞癌中的表达及其生物信息学分析。内蒙古医学院学报,2004(12);26(4):237-241。
45.赵力,冷希圣,彭吉润,牟东成,黄磊,魏玉华。4种肿瘤-睾丸抗原在肝细胞癌中的表达。中华实验外科杂志,2004(9);21(9):1049-1050。
46.牟东成,冷希圣,彭吉润,赵力, 王万祥,王远, 李涛,张利刚,黄磊,朱继业。黑色素瘤抗原MAGE-B亚家族基因在肝细胞癌中的表达。中华肿瘤杂志,2004(1 );26 (1 ):40-42。
47.Xiao-Ying Shang, Hong-Song Chen, Hua-Gang Zhang, Xue-Wen Pang, Huan Qiao, Ji-Run Peng, Li-Ling Qin, Ran Fei, Ming-Hui Mei, Xi-Sheng Leng, Sacha Gnjatic, Gerd Ritter, Andrew J. G. Simpson, Lloyd J. Old, and Wei-Feng Chen. The Spontaneous CD8+ T-Cell Response to HLA-A2-Restricted NY-ESO-1b Peptide in Hepatocellular Carcinoma Patients. Clin. Cancer Res., Oct 2004; 10: 6946 - 6955.
48.L Zhao, DC Mou, XS Leng, JR Peng, WX Wang, L Huang, S Li, and JY Zhu. Expression of cancer-testis antigens in hepatocellular carcinoma. World J Gastroenterol, Jul 2004; 10(14): 2034-2048.
49.HC Wang, YR Su, KJ Han, XW Pang, JR Peng, B Liang, S Wang, and WF Chen.Multiple variants and a differential splicing pattern of kinectin in human hepatocellular carcinoma. Biochem Cell Biol, Apr 2004; 82(2): 321-327.
50.王茂春,彭吉润,冷希圣,朱继业,杜如昱。计算机行肝脏CT断层三维重建及测量在肝癌中的应用研究。中国医学影像技术,2003;19(12):1735-1738。
51.王茂春,冷希圣,彭吉润,朱继业,杜如昱。肝硬变门静脉高压症患者肝体积测量研究及其临床意义。中国普外基础与临床杂志,2003(11);10 (6 ):586-592。
52.王万祥,冷希圣,彭吉润,牟东成,李涛,王远,张利刚,朱继业,杜如昱。CT10抗原基因在肝细胞肝癌中的表达及CTL表位预测。中华普通外科杂志,2003,18(1): 42-44
53.王万祥,冷希圣,彭吉润,牟东成,王瑜,朱继业,杜如昱,陈慰锋。肝细胞癌抗原基因在肝癌组织中的表达及临床意义。中华外科杂志,2003;41(7):506-508
54.王远,彭吉润,冷希圣,牟东成,朱继业,杜如昱。应用MAGE-3抗原肽诱导肝癌病人特异性免疫应答的体外研究。中华普通外科杂志,2003;18(3):136-138。
55.冷希圣,翁山耕,李涛,魏玉华,彭吉润,杜如昱。大鼠肝星状细胞系的建立及其生物学特性的研究。解剖学报,2003; 34 (3):269-274。
56.李涛,冷希圣,翁山耕,彭吉润,魏玉华,牟东成,王万祥,朱继业。5-羟色胺受体在肝星状细胞上的表达及5-羟色胺对肝星状细胞生物学活性的影响。中华外科杂志,2003;40(3);175-179。
57.彭吉润,蔡胜利,冷希圣,牟东成,吕建锋,陈红松,芮静安。用MAGE基因mRNA为标记检测肝癌病人外周血肿瘤细胞。中华外科杂志,2002;40(7):487-490。
58.DC Mou, SL Cai, JR Peng, Y Wang, HS Chen, XW Pang, XS Leng, and WF Chen. Evaluation of MAGE-1 and MAGE-3 as tumour-specific markers to detect blood dissemination of hepatocellular carcinoma cells. Br J Cancer, Jan 2002; 86(1): 110-116.
59.Yu Wang, Ke-Jun Han, Xue-Wen Pang, Hilary A. Vaughan, Wei Qu, Xue-Yuan Dong, Ji-Run Peng, Hai-Tao Zhao, Jing-An Rui, Xi-Sheng Leng, Jonathan Cebon, Antony W. Burgess, and Wei-Feng Chen. Large Scale Identification of Human Hepatocellular Carcinoma-Associated Antigens by Autoantibodies. J. Immunol., Jul 2002; 169(2): 1102 - 1109.
60.金仲田,张德恒,彭吉润,李澍,冷希圣。干扰素调节因子在自发免疫性甲状腺炎发病机制中的作用。中国实用外科杂志,2003;23(3):143-145。
61.牟东成,冷希圣,彭吉润,吕建峰,张佑彬,翁山耕,张利刚,朱继业,陈慰峰。 SSX1基因mRNA在肝细胞肝癌中的表达。中华实验外科杂志,2002;19(2):110-111。
62.吕建峰,冷希圣,彭吉润,牟东成, 庞学雯,商小英,陈慰峰。应用MAGE-1抗原肽从肝癌病人外周血中诱导产生特异性细胞毒T淋巴细胞。中华医学杂志(英文版)2002;115(7):1002-1005。
63.张佑彬,冷希圣,彭吉润,何湘君,吕建峰,翁山耕,王申五,杜如昱。携带抑癌基因的重组腺相关病毒载体的构建及病毒包装滴定方法探讨。中华医学杂志,2002;82(8):564-567。
[奖励]
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作为“液递物质在肝硬化门静脉高压症发病中的作用及其临床意义研究”课题组成员,1994年荣获卫生部科技进步三等奖。
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作为“新的肿瘤相关抗原的发现及其应用前景研究”课题组主要成员,荣获2007年度高等学校科学技术奖(教育部)自然科学一等奖、2007年度中华医学科技奖(中华医学会)自然科学二等奖以及2008年度北京市科学技术奖自然科学二等奖各一项。
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曾荣获北京大学医学部“优秀青年志愿者”、“优秀教师”等荣誉称号。 |